Extensively Drug-Resistant Acinetobacter baumannii

second patient were within the same subgroup, but similarity in nucleotide sequences was only 82.5%. This result suggests that this patient was infected with 2 different virus strains of HRV-A and a strain of HRV-C. Comparison of the HRV-A strains with the HRV-C strain showed that they belonged to different subgroups and had low similarity for nucleotide sequences. The second patient had 3 distinct rhinovirus infections over 3 months, and each was associated with illness requiring hospitalization. Both patients had underlying diseases, reactive airway diseases, and repeated episodes of RTI that may have rendered them vulnerable to reinfection, compromising their immune responses. Complete coding sequences of HRV-A and HRV-C have been determined (4,7). However, little is known about their involvement in the pathogenesis of recurrent wheezing in young children. According to recent reports, HRV-C has been detected in hospitalized children with lower RTI in the People’s Republic of China (5). Possible association of novel infection with HRV and exacerbation of asthma in children has also been reported (6). We report HRV-A and HRV-C coinfections in conjunction with other respiratory viruses, such as RSV, as a potential cause of recurrent wheezing in infants with acute lower RTIs. Coinfections with HRV-A and HRV-C may contribute to increased virulence and subsequent pathogenesis of other respiratory viruses. Additional studies will be required to further explore the clinical role of novel HRVs.